2026 College Football Week 1 Predictions and Odds

The 2026 college football season continues with Week 1, featuring a total of 90 games involving FBS teams. Notable matchups include Lane Kiffin's debut with LSU against Clemson, where LSU is favored by 10.5 points, and a ranked game between No. 9 Ole Miss and No. 24 Louisville.

Other significant non-conference games include UCLA facing Cal, and Baylor taking on Auburn, with Auburn favored by 7 points. Ohio State, the top-ranked team, is heavily favored at -50.5 against Ball State as they kick off their season.

SportsLine's model has simulated each FBS game 10,000 times, providing predictions for all matchups. Among its recommendations, Auburn is expected to cover against Baylor, while Cincinnati is favored to win against Boston College, reflecting the Eagles' struggles from the previous season.