2026 NFL Week 1 Odds: Cowboys Favored Against Giants, Panthers Face Bears
The 2026 NFL season is set to begin with a series of exciting matchups, including a rematch of Super Bowl LX between the Patriots and Seahawks in Seattle. The season opener will take place shortly, followed by an international game in Melbourne featuring the 49ers and Rams.
In the opening week, the Cowboys will face the Giants, with Dallas favored by 2.5 points despite a challenging road record last season. The Panthers, comfortable in their role as underdogs, will take on the Bears, while the Seahawks, coming off a championship season, will look to maintain their strong performance against the Patriots.
Other notable games include the Dolphins against the Raiders, both with new head coaches and quarterbacks, and the Eagles, who are favored against the Commanders after significant offseason changes. The week will conclude with the Chiefs hosting the Broncos, where Patrick Mahomes is expected to return from injury.
