49ers and Seahawks Set for NFC West Clash in Week 5

The San Francisco 49ers, who remain unbeaten at 4-0, will visit the Seattle Seahawks on Sunday for an NFC West matchup. The game is scheduled to kick off at 4:25 p.m. ET at Lumen Field in Seattle.

Quarterback Brock Purdy has been instrumental for the 49ers, contributing to their strong start, while the team's defense ranks seventh in yards allowed. The Seahawks, currently at 3-1, boast the top-ranked defense in yards allowed and have previously limited the 49ers to just nine points in their last matchup, which they won on their way to a Super Bowl victory.

Seattle is favored by 3 points, with an over/under set at 45.5 total points. The SportsLine projection model, which has a successful track record in NFL betting, predicts the game will exceed the point total based on offensive performances from both teams. Notably, the 49ers will be without edge rusher Nick Bosa, which may impact their defensive strategy.