49ers Place Mykel Williams on Reserve/PUP and Christian Kirk on IR

The San Francisco 49ers have announced that defensive end Mykel Williams will not participate in at least the first four games of the upcoming season as he is placed on the physically unable to perform list due to recovery from a torn ACL sustained last season.

Additionally, running back Isaac Guerendo will also remain on the PUP list as the regular season begins. Wide receiver Christian Kirk and offensive lineman Austen Pleasants have been moved to injured reserve with the possibility of returning later, while offensive linemen Brett Toth and Nick Zakelj are on IR without return eligibility.

In a series of roster moves, the 49ers waived or released multiple players, including defensive backs, defensive linemen, running backs, wide receivers, linebackers, offensive linemen, a punter, a long snapper, tight ends, and a quarterback.