Arizona Cardinals to Face Los Angeles Chargers in Week 1 NFL Matchup

The Arizona Cardinals are set to take on the Los Angeles Chargers on Sunday, September 13, 2026, at 4:25 p.m. ET at SoFi Stadium in Inglewood, California.

In 2025, the Cardinals led the NFL with 617 passing targets, with Trey McBride being a standout performer, averaging 84.8 receiving yards per game. The Chargers will rely on Khalil Mack, who is close to achieving 150 career tackles for loss.

The betting odds favor the Chargers, who are 9.5-point favorites, with a total set at 47.5. The Cardinals' backfield will feature Tyler Allgeier as the starter, while Jeremiah Love's status remains uncertain due to a high ankle sprain. For the Chargers, Mitchell's return from injury adds depth to their backfield alongside Omarion Hampton. Quarterback Justin Herbert is expected to lead the Chargers' offense after a strong preseason performance.