Buffalo Bills to Face Houston Texans in Week 1 Matchup

The Buffalo Bills are set to compete against the Houston Texans on Sunday, September 13, 2026, at 1 p.m. ET at Reliant Stadium in Houston, Texas.

Buffalo enters the game as a slight favorite, with a spread of -1.5. The Bills had a strong rushing performance last season, scoring 30 rushing touchdowns and leading the league with 1,793 fourth-quarter yards. The Texans, meanwhile, have won 10 of their last 11 games, presenting a challenge for Buffalo's late-game strength.

Buffalo's quarterback, who has shown promise in the preseason, will be crucial for the team's offensive strategy. The Bills are also ranked first in third down percentage before the season begins. For Houston, their quarterback will need to establish a rhythm early, especially with changes in the receiving corps. The Texans are looking to build chemistry among their players, particularly with a recent addition from a trade.