Cardinals Set to Face Rams in NFL Week 6 Matchup

The Arizona Cardinals are scheduled to play against the Los Angeles Rams on Sunday, October 18, 2026, at 4:05 p.m. ET at SoFi Stadium in Inglewood, California. The Rams currently hold a record of 2-3, placing them third in the NFC West, while the Cardinals are at 1-4, sitting in fourth place.

In their previous game, the Rams lost to the Buffalo Bills in overtime with a score of 37-34. Matthew Stafford had a standout performance, throwing for 383 yards and three touchdowns. Conversely, the Cardinals suffered a significant defeat against the Detroit Lions, losing 45-21, and saw Marvin Harrison Jr. traded to the Houston Texans shortly after the game.

The Rams are favored by 13.5 points, with a total of 52.5 for the game. Arizona has struggled with quarterback Jacoby Brissett being sacked 12 times this season. The Rams' defense has allowed an average of 156.8 passing yards per game, while the Cardinals' passing offense ranks in the lower half of the league.