Chargers to Face 49ers in Week 2 of NFL Preseason

The Los Angeles Chargers are set to host the San Francisco 49ers on Thursday for Week 2 of the 2026 NFL Preseason. This matchup features two cross-state rivals who have faced each other 45 times in preseason history, with the 49ers leading the series 26-19.

In their previous games, the 49ers lost to Tennessee 19-13, while the Chargers, led by former Niners quarterback Trey Lance, secured a 27-7 victory over Houston. Both teams are expected to have their starting quarterbacks, Justin Herbert and Brock Purdy, participate after sitting out the first week.

Kicking off at 10 p.m. ET from SoFi Stadium in Inglewood, California, the 49ers are currently favored by 1.5 points, with an over/under set at 38.5 points. Expert Jeff Hochman has analyzed the matchup and is predicting a lower-scoring game, leaning towards the Under based on previous trends and the absence of key offensive players for San Francisco.