College Football Week 1 Matchups: Clemson vs. LSU and Louisville vs. Ole Miss

Week 1 of college football is underway, showcasing major matchups such as Clemson versus LSU on Saturday and No. 24 Louisville against No. 9 Ole Miss on Sunday, the latter being the only game this week featuring two Top 25 teams.

The clash between Clemson and LSU will take place in Baton Rouge, with LSU's Lane Kiffin starting his new role amid a roster revamped through the transfer portal. Clemson's Dabo Swinney aims to reestablish the Tigers as contenders in the ACC and national championship race, with Christopher Vizzina stepping in as quarterback.

Meanwhile, Ole Miss, led by quarterback Trinidad Chambliss and running back Kewan Lacy, enters the season with high expectations following a strong playoff run last year. Louisville seeks to make a statement against a top SEC team. Sportsbooks like FanDuel and DraftKings are offering various betting options for these matchups.