LSU and Clemson Set for Week 1 College Football Clash

The LSU Tigers are scheduled to play against the Clemson Tigers in a significant Week 1 college football matchup on Saturday night, marking the start of their 2026 seasons. This game will feature Lane Kiffin's debut as head coach of LSU, where he will compete against Clemson's Dabo Swinney, a coach with four national championships to his name.

Last year, LSU triumphed in their opening game against Clemson with a score of 17-10. Both teams are looking to recover from disappointing 2025 seasons, with LSU finishing 3-5 in the SEC and Clemson ending at 4-4 in the ACC. The kickoff is set for 7:30 PM ET at Tiger Stadium in Baton Rouge, Louisiana. LSU is currently favored by 10 points, with the over/under set at 50.5 points.

The SportsLine Projection Model has simulated the game 10,000 times, recommending a bet on the Under for total points scored. Both teams are expected to feature new quarterbacks, with Clemson starting senior Christopher Vizzina and LSU opting for Arizona State transfer Sam Leavitt. The model predicts a total of 49 points will be scored, suggesting that betting on the Under is a favorable option.