NFL Week 2 Odds: Spreads and Matchups Overview

The NFL Week 2 matchups are set, featuring a notable Thursday night game between the Lions and the Bills in Buffalo.

As of September 14, the betting lines for each game at bet365 Sportsbook include the Bills favored by 3.5 points against the Lions, with a moneyline of Bills -185 and Lions +155, and an over/under of 53.5. Other matchups include the Falcons at -1.5 against the Panthers, Texans at -2.5 against the Bengals, and the 49ers heavily favored at -12.5 against the Dolphins.

Additional matchups feature the Ravens, Eagles, and Chiefs all favored by more than a touchdown, while the Packers and Bears also hold significant spreads. The betting landscape for these games reflects the competitive nature of the league as teams prepare for the upcoming week.