Ole Miss and Louisville Set for Week 1 Showdown in Nashville

The Week 1 college football schedule features a notable matchup as the No. 9 Ole Miss Rebels take on the No. 24 Louisville Cardinals on Sunday evening in Nashville. This game marks the beginning of a new era for Ole Miss under head coach Pete Golding, who steps in for Lane Kiffin after last season's College Football Playoff appearance. Heisman candidate quarterback Trinidad Chambliss returns, enhancing Ole Miss's prospects for the season.

Kicking off at 7:30 p.m. ET at Nissan Stadium, Ole Miss is favored by 6.5 points, with an over/under set at 55.5 points. The Rebels are listed at -255 on the money line. The SportsLine Projection Model, which has successfully simulated every FBS game 10,000 times, predicts a combined score of 49 points, suggesting the total will go under.

While Ole Miss boasts a strong offensive lineup, including Chambliss and running back Kewan Lacy, Louisville is expected to present a tough defensive challenge, having ranked in the top 40 for scoring and total defense last season. The Cardinals are led by NFL prospects Clev Lubin and A.J. Green on defense, aiming to contain Ole Miss's high-powered attack.