Panthers vs. Eagles Betting Preview for NFL Week 6

The Philadelphia Eagles will host the Carolina Panthers in NFL Week 6 on Sunday afternoon, featuring two division winners from 2025. The Panthers, coming off a bye week after defeating Detroit, hold a 2-2 record, while the Eagles, at 2-3, are reeling from a last-second loss in London.

Philadelphia will be without starting quarterback Jalen Hurts due to a blood clot issue, and running back Saquon Barkley is also sidelined with a hamstring injury. Receiver DeVonta Smith is expected to play. The game is set for a 1 p.m. ET kickoff at Lincoln Financial Field, with the Panthers favored by 3 points and an Over/Under of 39.5.

The Eagles have struggled offensively this season, and with Hurts out, Tanner McKee will take over as quarterback. Despite the challenges, the Eagles have averaged 25.9 points per game with other quarterbacks. In contrast, the Panthers have been performing well offensively, averaging 30.3 points per game, although their defense has allowed 27.3 points per game.