Preview of Monday Night Football: 49ers vs. Commanders

The San Francisco 49ers will take on the Washington Commanders in the final game of Week 6 on Monday Night Football. The Commanders, entering as 7.5-point underdogs, are expected to adopt a pass-heavy strategy due to their aggressive blitzing defense, which could benefit 49ers quarterback Brock Purdy and tight end George Kittle.

Brock Purdy has exceeded 250 passing yards in two of his last three games and holds an impressive PFF grade of 88.5, ranking second among quarterbacks this season. The Commanders' defense has struggled, ranking 27th in passing success rate and 26th in EPA allowed per pass play, while also ranking 24th in pressure rate despite a high blitz rate.

With the Commanders likely playing from behind, they may rely more on their passing game, especially with leading rusher Jacory Croskey-Merritt unavailable. The 49ers' offense, which ranks low in time of possession, could provide Washington with ample opportunities to throw. Additionally, Christian McCaffrey has been a key player for San Francisco, scoring in 11 consecutive games when favored and leading the team in red-zone touches.