Saints vs. Giants Betting Preview for NFL Week 6

The New Orleans Saints are set to play against the New York Giants in Week 6 of the 2026 NFL season on Sunday at MetLife Stadium, with kickoff scheduled for 1 p.m. ET. The Giants have had a strong start to the season, even after losing quarterback Jaxson Dart to a season-ending injury, and recently tied with the Commanders after a missed field goal in overtime.

New York enters the game as 1.5-point favorites, with an Over/Under of 46.5. The Saints, who have faced injury challenges including the absence of key players like Travis Etienne and Jordyn Tyson, have struggled defensively. Quarterback Tyler Shough has had difficulty against opposing defenses, notably throwing for under 100 yards last week against the Vikings.

Jameis Winston has stepped in for Dart, leading the Giants' offense effectively, and New York is averaging 21.8 points per game. Despite the setback from last week's tie, the Giants remain in first place in the NFC East. SportsLine simulations predict a 58% chance of a Giants victory, highlighting the inconsistency of the Saints this season.