Titans Face Colts in Week 6 NFL Matchup

The Tennessee Titans are set to take on the Indianapolis Colts on Sunday, October 18, 2026, at 1:00 p.m. ET at Lucas Oil Stadium in Indianapolis, Indiana. The Colts enter the game with a record of 2-3, while the Titans are struggling at 0-5.

In their previous game, the Colts lost 34-22 to the Pittsburgh Steelers, with Daniel Jones passing for 267 yards. Tyler Warren contributed to the Colts' offense with seven receptions for 83 yards and their only touchdown. Spencer Shrader also made five field goals, leading the NFL with 16 this season. Meanwhile, the Titans suffered a 26-3 defeat against the Houston Texans, marking their lowest scoring game of the season.

The Colts are favored by 7 points, with a total set at 44. Jonathan Taylor has been a key player for Indianapolis, scoring six rushing touchdowns this season. Tyler Warren's status is uncertain due to a groin injury, and he is considered a game-time decision. The Titans have struggled defensively, allowing 114 rushing yards per game, while their passing game has also been weak, ranking in the bottom five of the league.