USC Trojans Face Fresno State Bulldogs in Week 1 College Football Matchup

The USC Trojans, currently ranked 14th, will compete against the Fresno State Bulldogs in a Week 1 college football non-conference game on Friday night at the Los Angeles Memorial Coliseum.

USC aims to secure its second consecutive victory after finishing the previous season with a 9-4 record, while Fresno State, now part of the Pac-12, ended 2025 with a 9-4 overall record as well. The Trojans have a historical advantage, winning five of their six previous encounters, including a decisive 45-17 victory in 2022.

Kicking off at 9 p.m. ET, USC is favored by 21.5 points, with an over/under set at 51.5 total points. The SportsLine Projection Model, which simulates games 10,000 times, predicts a total of 54 points for this matchup, indicating a high-scoring game based on past performances.