Week 1 College Football Predictions and Odds for 2026 Season

The 2026 college football season continues with Week 1, featuring 90 games involving FBS teams. Notable matchups include Lane Kiffin's debut with LSU against Clemson, where LSU is favored by 10 points, and a ranked game between No. 9 Ole Miss and No. 24 Louisville.

Other significant non-conference games include UCLA facing Cal and Baylor taking on Auburn at a neutral site in Atlanta. Ohio State, ranked No. 1, is heavily favored against Ball State with a spread of -50.5.

SportsLine's model, which has simulated each FBS game 10,000 times, recommends Auburn covering the spread against Baylor and Cincinnati covering against Boston College. Auburn's quarterback Byrum Brown is expected to have a strong performance, while Boston College is coming off a challenging season.