Week 1 College Football Predictions: Notre Dame vs. Wisconsin and More

This Sunday, college football fans can look forward to three significant games, including No. 17 Washington against Washington State, No. 9 Ole Miss versus No. 24 Louisville, and No. 4 Notre Dame facing Wisconsin at Lambeau Field at 7:30 p.m. ET.

Notre Dame, which previously defeated Wisconsin 41-13 in 2021, is currently favored by 20.5 points. The over/under for this matchup is set at 46.5 points. SportsLine's model predicts a strong performance from Notre Dame, projecting a 39-12 victory and a 65% chance of covering the spread.

In the Apple Cup, Washington is expected to win against Washington State, with the model suggesting a 32-16 outcome while the Cougars are likely to cover the 23.5-point spread in 64% of simulations. Additionally, the matchup between Ole Miss and Louisville is anticipated to yield a total of 49 points, with the Under hitting in 60% of simulations.